A Structure-Based Strategy for New Drug Discovery

Peptide Architecture: Adding an α-Helix to PYY lysine side chain provides nanomolar binding and body weight lowering effects

Peptide hormone isoforms: N- terminally branched PYY3–36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice

Evaluation of the effects of Mitragyna Speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay

Cannabinoid 1 (CB1) receptor–pharmacology, role in pain and recent developments in emerging CB1 agonists

Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors

Demonstration of anti-tumor efficacy in multiple preclinical cancer models using a novel peptide inhibitor (Aurigene-012) of the PD-1 signaling pathway

Aurigene-012 as a novel peptide inhibitor of the PD1 signaling pathway – Identification of a preclinical drug candidate for cancer therapy, Natural Peptides to Drugs

Discovery of indole tetrafluoro phenoxymethyl ketone-based potent novel small molecule inhibitors of caspase-3

Investigation of orally administered small molecule inhibitors of caspase-3 in murine models of apoptosis