Developing Selective Inhibitors Of Ptp1b Over TcCPTP.

Synthesis and Biological Evaluation of 3-(4-aminophenyl)-2-(1H-indol-3-yl)Propanamide derivatives as novel PTP1B Inhibitors

Preliminary safety evaluation of novel small molecule inhibitors of caspase-3

Demonstration of anti-tumor efficacy in multiple preclinical cancer models using a novel peptide inhibitor (Aurigene-012) of the PD-1 signaling pathway

Identification of PI3K isoform selective inhibitors for treatment of inflammatory indications

Inhibition of matriptase results in efficacy in preclinical models of osteoarthritis

Diphenylether derivative as selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) over t-cell protein tyrosine phosphatase (TCPTP) identified through virtual screening

Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors

Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode

Discovery of PyridylBis(oxy)benzamide Derivatives as Selective Matriptase Inhibitors