AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei – Crystal structure, mode of action, and biological activity

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signaling and disrupting epithelial cohesion

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors

Discovery of dihydro-isoxazole derivatives as novel inhibitors of NAMPT for the treatment of multiple myeloma, (NAMPT)

Novel IRAK-4 inhibitors exhibit highly potent anti-proliferative activity in DLBCL cell lines with activating MYD88 L265P mutation (IRAK-4)

Potent and selective inhibition of CDK7 by novel covalent inhibitors

Pre-clinical efficacy in multiple syngeneic models with oral immune checkpoint antagonists targeting PD-L1 and TIM-3

ODM-207, a novel BET-bromodomain inhibitor as a therapeutic approach for the treatment of patients with castration resistant prostate cancer

ODM-207, a novel BET-bromodomain inhibitor as a therapeutic approach for the treatment of prostate and breast cancer