Structure-Guided Discovery of 1,3,5 Tri-Substituted Benzenes as Potent & Selective Matriptase Inhibitors Exhibiting in Vivo Antitumor Efficacy

Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors

3Alkoxy-pyrrolo[1,2b]pyrazolines as Selective Androgen Receptor Modulators with Ideal Physicochemical Properties for Transdermal Administration

Identification of a potent inhibitor of enoyl ACP reductase FabI from Burkholderia pseudomallei – crystal structure, Mode of Action and Biological Activity

Discovery and Optimization of a Novel Series of IRAK-4 Inhibitors for the Treatment of Autoimmune Disorders

Efficacy of Selective RAR-related Orphan Receptor gamma (RORγ) Inverse Agonists in Inflammatory Disease Models

Discovery of O-(3-carbamimidoylphenyl)-L-serine amides as matriptase inhibitors using a fragment-linking approach

Crystal structure of ATP-binding subunit of an ABC transporter from Geobacillus kaustophilus

Dihydroorotate Dehydrogenase (DHODH) Inhibitor Suppress Breast Cancer Cells Proliferation

AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei – Crystal structure, mode of action, and biological activity