Identification of potent BET bromodomain inhibitors for treatment of cancer

Equipotent antagonism, transient immune activation and excellent antitumor efficacy with a peptide inhibitor of PD-1 immune checkpoint pathway

Discovery of potent & selective retinoid related orphan receptor gamma (ROR-gamma) inverse agonists for the treatment of TH17 mediated diseases

Equipotent antagonism towards both ligands and excellent anti-tumor efficacy with a peptide inhibitor of PD-1 immune checkpoint pathway

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia

Novel inhibitors of nicotinamide phosphoribosyltransferase and their evaluation in combination with bortezomib

X-ray structure of PTP1B in complex with a new PTP1B inhibitor

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

Structure-Guided Discovery of 1,3,5 Tri-Substituted Benzenes as Potent & Selective Matriptase Inhibitors Exhibiting in Vivo Antitumor Efficacy

Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors